Protein Folds: A Distance-Based ApproachCRC Press, 1995 M10 20 - 336 pages Written by outstanding scientists in physics and molecular biology, this book addresses the most recent advances in the analysis of the protein folding processes and protein structure determination. Emphasis is also placed on modelling and presentation of experimental results of structural membrane bound proteins. Many color plates help to illustrate structural aspects covered including: All analysis is presented with proven theory and experimentation. Protein Folds: A Distance-Based Approach is an excellent text/reference for biotechnologists and biochemists as well as graduate students studying in the research sciences. |
Contents
Three Paradoxes of Protein Folding 3 | 13 |
Conserved Water Molecules and Protein Folding in Fungal Peroxidases | 21 |
Interplay between Metal Coordination Geometry and Protein Structure | 31 |
A Gprotein in Protein Biosynthesis | 43 |
Pseudomonas stutzeri cytochrome c4 | 56 |
Sequence Matching in Homology Modeling | 71 |
Screening Genome Sequences for Known Folds | 80 |
vi | 98 |
Using Sequence Information and Model Building to explore Subtype | 174 |
Proposed Rules of the Protein Folding Game | 189 |
Protein Folding Studied by Monte Carlo Simulations | 202 |
Folding Kinetics of Protein Like Heteropolymers | 218 |
Energy Landscape and Folding Mechanisms in Proteins | 233 |
The Implication of Topology for Protein | 243 |
Chirality in Protein Structure | 253 |
Packing Within And Between Subunits Defined By Internal Cavities | 265 |
The Effect of a DistanceCutoff on the Performance of The Distance Matrix | 105 |
How Selfmisleading can be avoided | 114 |
Identification of Functionally or Structurally | 124 |
Fitting 1D Predictions into 3D Structures | 132 |
Modelling ahelical Integral Membrane Proteins | 155 |
Use of Small Organic Compounds and Metalions as structural | 165 |
Common terms and phrases
2SCP 3-D structure a-helices Acad algorithm amino acid analysis atoms backbone bacteriorhodopsin binding Biochem Biol Ca2+-binding calculated cavities cDME Chem chirality complex computed conformational search conserved coordination geometry corresponding crystal structure cytochrome c4 database determined distance geometry distance restraints domains EF-Tu energy landscape entropy experimental structure Figure folding funnel G-proteins glass transition global globular proteins GPCR helices helix heme group heteropolymer homologues homology modelling hydrogen bonds hydrophobic interaction kinetics lattice model Levinthal Levinthal paradox ligands loop mechanism method minimal monomers Monte Carlo motifs mutation native fold native structure Natl optimal P. G. Wolynes paradox parameters peptide peroxidase photoproteins Phys polypeptide chain Proc protein folding protein sequences protein structure random receptor region remote homologues residues rhodopsin score secondary structure segments sequence alignment Shakhnovich shown similar simulations solvated solvent accessibility structure prediction surface tertiary structure topology transmembrane values water molecules X-PLOR